Cardiovascular disease (CVD) due to atherosclerosis is the most common cause of death of both men and women in developed countries. Despite a lower age-related risk, ultimately more women die of CVD compared to men. Women are also disadvantaged at all stages of diagnosis and management of CVD. Mortality from acute coronary events is higher in women. Even though the lifetime risk in women (1 of 2) is very high, majority of deaths from CVD is preventable in women. Since women develop CVD 10 year later, increased prevalence of associated diabetes, hypertension, and dyslipidemias and other components of metabolic syndrome need special consideration in women with CVD. Therefore, gender-specific approach and awareness of women at risk is crucial. In this review, current evidence and guidelines were discussed according to pathogenesis, risk factors, diagnosis, and treatment of CVD in women.