Rabies, associated with the highest fatality rate among all infectious diseases, is endemic throughout the world. Currently, postexposure vaccination is the method of choice for pre-vention of rabies. Although the rabies vaccine is a live virus vaccine, pregnancy and breast-feeding are not contraindications for vaccination. In high risk patients, pre-exposure vaccina-tion in pregnancy is also possible. In this, review vaccination schemes during pregnancy and lactation were discussed along with the new developments in rabies vaccines and diagnosis of rabies.